Are you talking about the door in the Lichs study? (the one that looks like stained glass and is a level 12 lock?) or are you talking about the one in the dungeon that leads to Madda Mabbig?
Adrianna has the key for the stained glass I think - she offers that or a a ring From the lich to you after you go to the dungeon and retrieve scroll of banishing and give it to her. The ring is nice but if you havent got the patch the minute you equip it you will crash.
The key (i think) is to that door.
Madda Mabbig can only be accessed after you give the relic to the Lich and he gets ganked by cet. He gives you his staff - use the staff on the door to Madda
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