I don't remember having to have it equipped, but for the person with the quest.
When you get close to Mekdawa, have the potion ready in your Use/Give icon with the word "give" highlighted.
Get close, click on Mekdawa & let him talk "Mekdawa need this, Toads need this...blah blah, blah...goodbye Ukabu!" & follow him until he is done speaking to be sure they will know at the guild that you completed the quest.
: )
Moni
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