Howdy,
My understanding was that the key from Adrianna opens the door in the Lich's study. If you've tried picking it, you'll notice that a level 12 Thief has some trouble, but its doable. Maybe having level 5 lockpicks makes it easy, but it can be done.
I had already looted the place, then I tried the Vampire Ring, which of course back when I was playing in the pre patch days, it would crash the game big time. So, I opted for the key and thought I'd missed something.
And I found that the key did open the door in the study, but being that you can pick it open, I find picking the key to be quite lame.
The Vampire Ring is a helluva item, and supposedly stops a vampires bloodthirst...but I'm not sure what it does if you are not one.
Hope this helps!
Scronan
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