Hi, first of all, welcome to the board!
Well, I don't think there is a definitive answer to your question, but there are some things that can be of influence. First, what level are you? If you have a very low level then obviously you'll encounter more difficulties in a fight. Second, are you playing the game for the first time, and do you have any experience with this sort of game? I think that as you continue playing, you'll learn from experience what techniques work best for you. It's probably the most fun if you find out for yourself, rather than read every single cheesy tactic here. If you get sick of the constant reloading, you will find valuable help here, but for the first time you play the game, I think it is unavoidable that you will have trouble - unless you get advice.
Have fun!
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Melusine, Archbabe of the Order of the Holy Flame and the Laughing Hyenas, &
Official Entertainer Elf of the BG2 Bar
Your voice is ambrosia