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Some notes on using area of effect spells (strategy spoilers):
1. You can equip your fighters with missile weapons so that they don't run into the area of effect. I find that a combination of web and cloudkill/deathfog are very effective for killing off large groups. Death fog automatically dispells summoned (but not gated) creatures.
2. Equip melee fighters with heavy fire resistance (above 100%) and fireball will not hurt them.
3. If you have a hasted character run into the middle of a cloudkill then turn invisible the monsters will run to the point where he disappeared and stand there and take damage. This works best if it is the same person who cast the cloudkill because sometimes the monsters will know who it was and come after them.
4. You can run around the edge of a cloud and the monsters will run through it trying to catch you, taking damage all the time.
Finally, negative plane protection is essential for fighting vampires (though the duration is short) and chaos for fighting mind-flayers.
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