Cloudkill works, but it usually just hurts 'em badly, rather than killing them.. Death fog is usually more effective.
The reason those mindflayers will kill you so quickly, regardless of HP is 'cos they drain 5 pts of intellegence w/ every successful hit, and when you hit 0 you're dead. Skeletons are perfect 'cos they can't be blasted or mind-controlled, and don't have any intellegence to drain. I /think/ that protection from normal weapons works too, so they can't hit you, although I could be wrong on that count.
For beholders, Spell deflection, and Spell Turning are your friends, and can reflect thier attacks back.
If you have the cloak of reflection on a tank, combined w/ haste or improved haste, all the beholder family is EASY to slaughter.
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