[andrewas]

Kangaxx is about as dangerous as a two year old, once you protect yourself from his endless imprisonments. Of course you have to get through his guardians first, which can be a pain cos you dont want to waste precious Protection Scrolls on them, but there far from impossible. I usuialy do him in in chapter 2 or 3. Never been to spellhold without at least one ring of Gaxx on my mage.
(you can pickpocket at the right moment for a second, but this is cheating)

Twisted Rune on the other hand, multiple high-end magic users, no way you can get through that without some deaths. But then I havent really studied up on high-level magic strategy.