[andrewas]

Normal config is HDD on C, CDROM (or similar) on D and that leaves E as the next drive letter. They should say "next available drive letter" but these manuals are never very well written. Its unlikely that its hardcodes to only work on drive E, but you can change the CD drive letter by right clicking on it in "my computer" and going into properties.

But it will almost certainlf appear on F when you get it working. When you got your camera there was a floppy/CD with it, yes? Did you install the drivers on that? These things are plug and play, but without the drivers they still dont work. Do you see anything happen when you plug it in? A USB connection should notify windows to ask for the driver disk, but serial wont.